Domperidone

Domperidone Generic name: domperidone Brand names: Motilium, Nauzelin, Domstal, Euciton, Moperidona, Vometa, Zilium and more Dosage form: oral tablet, oral suspension, oral drops, orally disintegrating tablet, suppository Medically reviewed by • • • • • • What is domperidone? Domperidone is an antiemetic (anti-sickness) and prokinetic drug. It belongs to a group of drugs called dopamine antagonists. It is used to treat stomach-related issues, such as Domperidone works by blocking dopamine receptors in the gut. It increases the movement or contractions of the muscles in your stomach and intestines, increasing how quickly and easily food moves through your digestive tract. It also acts on the chemoreceptor trigger zone in your brain, which is involved in nausea and vomiting. This area of your brain is outside the blood-brain barrier. Unlike other dopamine antagonists, domperidone does not cross the blood-brain barrier, which minimizes central nervous system (CNS) side effects. Domperidone works to boost breastmilk supply by increasing the level of a hormone called prolactin, which stimulates the production of breastmilk. Domperidone is available on prescription and in some places as an over-the-counter (OTC) medicine. It is available in many places around the world, including the UK, Europe, Canada and New Zealand. Approved uses of the drug vary from country to country. It is also used for off-label or unapproved conditions, including boosting breastmilk supply. Domperidone ...

Domperidone, first synthesized approximately 40 years ago, has been approved worldwide for specific clinical applications. However, in the United States it is only available through an FDA-approved Limited Access Program. In this article we review all the literature regarding its clinical efficacy and we provide a comprehensive list of recommendations and guidelines when considering initiating domperidone in patients that are suitable for this medication. Domperidone, first synthesized approximately 40 years ago, has been approved worldwide for specific clinical applications. However, in the United States it is only available through an FDA-approved Limited Access Program. Patients with functional dyspepsia, gastroparesis, gastroesophageal reflux disease and refractory nausea and vomiting may benefit from the use of domperidone. The main limitation to using domperidone has been questions raised regarding cardiac toxicity, specifically QTc elongation that could potentially lead to fatal arrhythmias. Recent studies have not shown a significantly increased incidence of cardiac side effects even when domperidone was given at very high doses, two to three-fold greater than those typically described in the majority of the available literature. In this article we review all the literature regarding its clinical efficacy and we provide a comprehensive list of recommendations and guidelines when considering initiating domperidone in patients that are suitable for this medication. M...

Proper Use Drug information provided by: Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. • For oral dosage form (tablets): • Treatment of gastrointestinal motility disorders: • Adults—10 milligrams (mg) three to four times daily. Some patients may require higher doses up to 20 mg three or four times daily. • Nausea and vomiting: • Adults—20 milligrams (mg) three to four times daily. Missed Dose If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed.